UC Davis Health gastroenterology researchers have received a $2.8 million grant from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) of the National Institutes of Health (NIH) to study the mechanisms of cell therapy using an AI-based digital pathology tool.
The four-year study will further investigate regenerative therapies, particularly using stem cells, to help treat chronic inflammatory conditions. It will also focus on how AI can assist pathologists in scoring damaged and affected tissue more quantitatively.
“We’re excited to be advancing cell-based therapies while also developing new tools to more precisely measure and assess tissue damage,” said Maneesh Dave, professor of gastroenterology and principal investigator of the study. “By deepening our understanding of these treatments, we hope to pave the way for novel therapies that could transform how chronic inflammatory conditions are managed.”
In earlier studies, Dave and his team investigated the therapeutic effects and mechanisms of mesenchymal stem cells (MSCs) as treatments for Crohn’s disease. Their research revealed that MSCs promote sustained tissue healing through a two-stage process.
As part of the new grant, Dave will collaborate with Satish Viswanath at Emory University to develop an innovative tool called the Inflammation Digital Pathology Tool. This AI-powered platform aims to revolutionize how researchers analyze tissue samples in studies of intestinal inflammation.
The team is leveraging a collection of digitized histopathology slides from mouse models, including those used in MSC research and other studies of inflammatory bowel disease (IBD) and graft-versus-host disease (GVHD). These slides, scanned at ultra-high resolution, form a growing database of over 700 samples, with plans to expand to more than 1,000.
Traditionally, pathologists look at tissue slides and estimate how much of the area is affected. While this has long been considered the gold standard for assessing disease and treatment response, it is a time-consuming and subjective process that relies heavily on human judgement.
To ensure accuracy, the team is working closely with a veterinary pathologist to validate the AI’s findings and refine the system. The hope is that the tool will not only match human-level precision but also uncover subtle patterns that the human eye may miss.
Additional collaborators on the grant include Richard Levenson, professor of pathology and Laboratory Medicine; William Murphy, distinguished professor of immunology; and Pedro Ruivo, health sciences clinical assistant professor.
