A leading drugmaker ramped up its lobbying in Canada fivefold last year, urging government officials to enact a rule that would give it an effective monopoly on long-acting narcotic painkillers.
Purdue Pharma’s efforts came as the government pledged a new attack on the county’s deadly opioid crisis. The privately owned maker of the blockbuster OxyContin pushed for a requirement that all long-acting narcotic painkillers, known as opioids, be made tamper resistant. The company, which sells the only tamper-resistant, long-acting opioids in Canada, met with 40 officeholders last year, up from eight in 2015 and three in 2014, records show.
The rule it proposed could edge out companies that don’t sell tamper-resistant opioids, including Novartis’, Sandoz AG
Health Canada issued a statement last April saying it had no plans to require tamper resistance. Purdue sent lobbyists on four occasions to Health Canada officials last year, including a May meeting seeking an explanation for the government’s stance, department spokesperson Anna Maddison said in an email.
Conservative Member of Parliament Kevin Sorenson revived the idea in September with a bill to require all controlled substances be tamper resistant. Records show Sorenson met with Purdue representatives six days before he introduced the bill and spoke with them again two days before it went to second reading in November.
Purdue’s lobbying illustrates the stakes for drugmakers in efforts to curb what policymakers have called North America’s biggest public health crisis. Canada’s $881-million annual opioid sales are dwarfed by the U.S. market, the biggest in the world. Any action by Canada is likely to attract interest south of the border.
Purdue said it was pushing for the rule to improve safety. Canadian officials have passed on that proposal and instead are looking at measures that could hurt sales of long-acting opioids, including Purdue’s best-selling painkillers.
Long-acting opioids contain high doses of narcotics designed to be released over time. If crushed pills are snorted or injected, they release their full dose all at once, which makes them dangerous and valuable among addicts. In 2012, Purdue replaced OxyContin with tamper-resistant OxyNEO in Canada and now wants that standard mandated for all long-acting opioids.
Many experts and public health officials see the research differently. They said there’s little evidence tamper resistance reduces addiction or death and that it may even prompt doctors to more readily prescribe opioids. Research shows opioids are most often abused not by crushing but by swallowing pills whole, said David Juurlink, a drug-safety researcher at Toronto’s Sunnybrook Health Sciences Centre. “It’s very easy to get the sense that this push in favor of tamper-resistant opioids is rooted more in financial considerations than in the public interest,” he said.
Generics manufacturers said they do not view tamper resistance as the answer. “We believe that efforts should be made to address the main root cause of opioid abuse and misuse, which appears to be over-prescribing,” Jeff Connell, Canadian Generic Pharmaceutical Association Vice-President, said in an email.
“There is no evidence that tamper-resistant formulations are effective in reducing the level of abuse of opioids,” a Sandoz spokesperson wrote in an email. Sandoz sells a long-acting, crushable oxycodone painkiller.