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February 3, 2025 – News Podcast


Rene Thomas Folse, JD, Ph.D. is the host for this edition which reports on the following news stories: SEIU Nurses Union to pay $6.28M for Unlawful Hospital Strike. No Tort Recovery After Employee Loses Wrongful Discharge Case. FTC Releases New Report – PBMs Markup Generics by 1000%. Cal/OSHA increases civil penalty amounts for 2025. Agenda Announced for DWC 32nd Annual Educational Conference. Recent Medical Workforce Trends on Injured Workers. Independent Pharmacies Won’t Carry Negotiated Price Drugs. AI Assisted Electrocardiogram Detects Cognitive Decline.

Cal/OSHA Fines Plumbing Companies $530K for Trench Collapse

The Division of Occupational Safety and Health, known as Cal/OSHA, has cited employers Smelly Mel’s Plumbing and Sewer Rat Plumbing a total of $529,640 in proposed penalties for violating safety regulations that resulted in serious injuries to a construction worker during a trench collapse in San Mateo on August 1, 2024.

Cal/OSHA, a division of the Department of Industrial Relations, found a total of 16 violations, evenly split between both businesses. Among these citations were two willful, serious accident-related violations – meaning the businesses were aware of the safety hazards, had prior warning, and still failed to take corrective action.

On August 1st, 2024, a crew was handling a sewer line project at a private residence in San Mateo. The job took a near-deadly turn when the walls of the trench collapsed, burying a worker under the debris and causing serious injuries that required hospitalization.

The citations issued include violations for improper protective systems, inadequate training, and failure to inspect the trench and surrounding conditions including:

– – Inspection Failure: Employers did not ensure that a competent person conducted daily inspections of the trench, adjacent areas, and protective systems that could have detected hazardous conditions such as cave-ins.
– – Lack of safe exit routes: Both employers failed to provide the construction workers a ladder or other safe means of exiting the trench that was approximately 9 feet and 3 inches in depth.
– – No adequate protective systems in trench: Neither employer provided adequate protective systems, such as shoring, shielding, sloping, or benching to the trench to prevent its collapse.
– – Failure to protect workers from falling debris: Neither employer protected their workers from excavated materials or equipment that could pose a hazard by falling or rolling into the trench.
– – Foot Protection: The employer failed to ensure that their workers had proper foot protection, which exposed at least one worker to foot injuries when using a jackhammer.
– – Insufficient emergency medical provisions: The employers did not have an appropriate number of trained persons to render first aid at the jobsite.
– – Permit Requirements: The employers failed to notify the division prior to the start of the annual permit-required activity of constructing an excavation over 5-feet in depth.
– – Injury and Illness Prevention Program: The employers failed to conduct a toolbox safety meeting at the jobsite with the crew for the duration of the project.

Employers have the right to appeal any Cal/OSHA citation and notification of penalty by filing an appeal with the Occupational Safety and Health Appeals Board within 15 working days from the receipt of notification.

Cal/OSHA Chief Debra Lee said “Trench collapses remain one of the most serious hazards in construction, and employers must take all necessary steps to protect their employees. These citations serve as a reminder that businesses must prioritize worker safety, especially during high-risk operations to avoid tragic accidents.”

SoCal Man Pleads Guilty to $17M Hospice Fraud

A California man pleaded guilty to health care fraud, aggravated identity theft, and money laundering in connection with a years-long scheme to defraud Medicare of more than $17 million through sham hospice companies and his home health care company.

According to court documents, Petros Fichidzhyan, 43, of Granada Hills, engaged in a scheme with others to operate a series of sham hospice companies. Fichidzhyan, along with co-schemers, impersonated the identities of foreign nationals to use as the purported owners of the hospices – including using the identities to open bank accounts and sign property leases – and submitted false and fraudulent claims to Medicare for hospice services that were not medically necessary and not provided. In submitting the false claims,

Fichidzhyan and his co-schemers also misappropriated the identifying information of doctors, claiming to Medicare that the doctors had determined hospice services were necessary, when in fact the purported recipients of these hospice services were not terminally ill and had never requested nor received care from the sham hospices.

As a result of the scheme, Medicare paid the sham hospices nearly $16 million. Fichidzhyan personally received nearly $7 million of the proceeds from the fraud scheme, including more than $5.3 million in transfers to his personal and business bank accounts, which were laundered through a dozen shell and third-party bank accounts.

Fichidzhyan additionally admitted to wrongfully obtaining more than $1 million for his home health care agency through the fraudulent use of a doctor’s name and identifying information in certifying Medicare beneficiaries for home health care, which he attempted to cover up by paying the doctor $11,000.

Fichidzhyan pleaded guilty to health care fraud, aggravated identity theft, and money laundering. He is scheduled to be sentenced on April 14 and faces a mandatory penalty of two years in prison on the aggravated identity theft charge, a maximum penalty of 10 years in prison on the health care fraud charge, and a maximum penalty of 20 years in prison on the money laundering charge. A federal district court judge will determine any sentence after considering the U.S. Sentencing Guidelines and other statutory factors.

Today’s guilty plea is the most recent conviction in the Justice Department’s ongoing effort to combat hospice fraud in the greater Los Angeles area. Last year, a doctor was convicted at trial for his role in a scheme to bill Medicare for hospice services patients did not need, and two other defendants were sentenced for their roles in a hospice fraud scheme.

Couple Plead Guilty to Home Health Care Fraud

Rafael Castro, a veteran of the U.S. Navy and a former employee of the Veterans Health Administration and the Internal Revenue Service, and his wife, Miriam Castro, pleaded guilty in federal court to defrauding the Department of Veterans Affairs (VA) out of more than $130,000.

According to their plea agreements, between September 2018 and April 2024, the Castros lied to obtain caregiver benefits from the Caregiver Support Program, a VA program that provides caregiver support for injured veterans. Rafael Castro admitted that he lied about needing high-level assistance for daily activities, including dressing and undressing himself, personal hygiene, and grooming.

According to plea documents, Rafael Castro defrauded the VA into awarding him assistance that paid the primary caregiver – his wife – an amount equivalent to a full-time home health aide’s 40-hour per-week payment.

According to plea documents, for years, Miriam Castro received monthly payments to be a full-time caregiver for Rafael Castro while her husband worked as a full-time federal employee. From July 2015 to June 2023, Rafael Castro worked for the Veterans Health Administration, and from June 2023 to April 2024, he worked for the Internal Revenue Service. Even though he was employed by the federal government, Rafael Castro falsely told VA representatives at least six times that he was unemployed.

For example, during a 2023 interview, Rafael Castro falsely claimed that he had last worked in 2018 and that his wife was his full-time caregiver. According to their plea agreements, while Rafael Castro was engaged in the fraud scheme, he received several promotions, all while he continued to claim he was unemployed. In their respective plea agreements, Rafael Castro and Miriam Castro admitted that they participated in the multi-year scheme to defraud the VA.

“This case is an excellent example of the importance of internal inspections within government programs,” said U.S. Attorney Tara McGrath. “Without the intervention from the Inspector General’s Office, this fraud might have continued indefinitely.”

“These guilty pleas demonstrate that those involved in defrauding VA, including government employees, will be held accountable,” said Special Agent in Charge Anthony Heddell with the Department of Veterans Affairs Office of Inspector General’s Western Field Office. “The VA OIG will continue to work with our law enforcement partners to ensure the integrity of VA’s benefits programs and services.”

“Violations of federal law, particularly those committed by IRS employees will not be tolerated and will be prosecuted to the fullest extent of the law,” Acting Special Agent in Charge Brandon Knarr stated. “TIGTA will continue to work closely with the United States Attorney’s Office and our law enforcement partners to identify, investigate and hold those individuals responsible for their illegal activities.”

Sentencing is scheduled for April 25, 2025, at 9 a.m. before U.S. District Judge James E. Simmons, Jr. This case is being prosecuted by Assistant U.S. Attorney Edward Chang.

Researchers Say Hybrid AI Approach Helps Brain Surgery Planning

AI-powered tractography is a cutting-edge technique that leverages artificial intelligence to enhance the visualization of nerve pathways in the brain. This method is particularly useful for planning complex neurosurgical procedures.

Tractography is an imaging technique that calculates the course of nerve pathways (also known as nerve fibers or tracts) based on specialized MRI scans. These pathways are crucial for various brain functions, including movement, speech, and thought. Traditional tractography methods rely on mathematical models to infer the location of these pathways from MRI data. However, these methods often involve uncertainties, especially when the brain has been altered due to disease or surgery.

Tractography, the process of reconstructing streamlines that represent neural fiber pathways within the human brain from diffusion MRI (dMRI), has gained significant attention in recent years. It is primarily used for scientific studies and surgical planning. TractSeg is a widely used example of this, automatically reconstructing specific fiber bundles with high precision.

Modern AI methods, such as machine learning, can recognize patterns in MRI data and generate more accurate reconstructions of nerve pathways. One widely used AI method is called TractSeg, which was originally trained on healthy brains. Researchers have tested whether TractSeg can also work for epilepsy patients who have undergone a hemispherotomy – a surgical procedure that disconnects the two hemispheres of the brain.

While TractSeg performed well in many cases, it also produced unexpected errors, such as reconstructing nerve pathways that should no longer exist due to the surgery-a phenomenon known as “hallucination.” Additionally, some remaining pathways were either incompletely captured or entirely missing from the reconstruction2.

To address these issues, a research team from the Lamarr Institute and the University of Bonn has developed the new hybrid method that combines the advantages of AI with the data fidelity of traditional techniques. This approach ensures that only existing nerve connections are reconstructed, eliminating the issue of “hallucinations” where AI might reconstruct pathways that no longer exist due to surgery.

Despite its good overall generalization, TractSeg failed to reconstruct some bundles, due to disconnected bundle masks, or because the start or end regions did not overlap the bundle mask.

Researchers concluded by saying “Although the results are promising, we advise caution and manual quality control when dealing with complex and severely pathological cases. We expect that fully automated and reliable generalization to pathologies that were not seen during training will remain a challenge for the current generation of deep learning based approaches.”

Unless Open & Obvious, Injured Worker Must Request Accommodations

Yukio Taira began working for Honeywell International, Inc. in November 2011. On May 14, 2015, Taira was on a flight to a trade show in Georgia when he suffered a “catastrophic stroke.” The flight was diverted and Taira was taken by ambulance to a hospital.

On June 29, 2015, Taira filed two applications for workers’ compensation benefits. One case listed a specific date of injury (May 14, 2015) – the date of his stroke. The other case listed an injury date of November 1, 2011, through May 14, 2015, the entire duration of Taira’s employment with Honeywell.

On September 11, 2018, Taira entered into a partial settlement agreement of $1,125,000 regarding both workers’ compensation cases. In October 2023, he settled the remaining issues in his cases for an additional $6 million, and the Workers’ Compensation Appeal Board approved that settlement.

On September 6, 2018, Taira filed a lawsuit alleging that Honeywell violated the Fair Employment and Housing Act (FEHA) by failing to provide him an accommodation for his disability (Gov. Code, § 12940, subd. (m))1 and failing to engage in the interactive process (§ 12940, subd. (n)). The third amended complaint, which is the operative pleading, alleges FEHA claims against Honeywell for failure to provide a reasonable accommodation (§ 12940, subd. (m)) and failure to engage in the interactive process (§ 12940, subd. (n)).

On June 16, 2022, Honeywell filed its motion for summary judgment which the trial court granted. Because the undisputed evidence establishes that Taira never requested a reasonable accommodation, the Court of Appeal affirmed the judgment in the unpublished case of Taira v. Honeywell International -B328410 (February 2025).

At issue in this appeal is only the question of whether Honeywell failed to reasonably accommodate Taira’s assumed disability.

“‘[I]t is important to distinguish between an employer’s knowledge of an employee’s disability versus an employer’s knowledge of any limitations experienced by the employee as a result of the disability.’” (Scotch, supra, 173 Cal.App.4th at p. 1013.) Thus, FEHA “requires an employer to accommodate only a ‘known physical . . . disability.’” (Avila v. Continental Airlines, Inc. (2008) 165 Cal.App.4th 1237, 1252.) “‘“Vague or conclusory statements revealing an unspecified incapacity are not sufficient to put an employer on notice of its obligations under the [FEHA].”’” (Featherstone v. Southern California Permanente Medical Group (2017) 10 Cal.App.5th 1150, 1167 (Featherstone).)

And, “the employee must request an accommodation.” (Gelfo, supra, 140 Cal.App.4th at p. 54.) “‘“Where the disability, resulting limitations, and necessary reasonable accommodations, are not open, obvious, and apparent to the employer,”’” the employee bears the burden “‘“to specifically identify the disability and resulting limitations, and to suggest the reasonable accommodations.”’” (Doe v. Department of Corrections & Rehabilitation (2019) 43 Cal.App.5th 721,738–739; see also Spitzer v. Good Guys, Inc. (2000) 80 Cal.App.4th 1376, 1378; Raine v. City of Burbank (2006) 135 Cal.App.4th 1215, 1222 (Raine).)

In other words, “[a]n employee cannot demand clairvoyance of his employer. [Citation.] ‘“[T]he employee can’t expect the employer to read his mind and know he secretly wanted a particular accommodation and sue the employer for not providing it. . . .”’ ‘It is an employee’s responsibility to understand his or her own physical or mental condition well enough to present the employer at the earliest opportunity with a concise list of restrictions which must be met to accommodate the employee.’ [Citation.]” (King v. United Parcel Service, Inc. (2007) 152 Cal.App.4th 426, 443 (King).)

There is no evidence that Taira informed Honeywell of specific work restrictions as a result of his disability or that he requested a reasonable accommodation. (See, e.g., Arteaga v. Brink’s, Inc. (2008) 163 Cal.App.4th 327, 349 [affirming summary judgment to the employer because although it learned of the plaintiff’s symptoms, “those symptoms did not interfere with the performance of his job”]; King, supra, 152 Cal.App.4th at p. 444 [given the plaintiff’s apparent ability to get the job done, “it was incumbent upon him to produce clear and unambiguous doctor’s orders restricting the hours he could work”].) Thus, Taira’s claim under section 12940, subdivision (m), fails.

For the same reason, Taira’s claim under section 12940, subdivision (n), fails. It is undisputed that Taira did not identify a specific, available reasonable accommodation while working at Honeywell. Absent this evidence, Honeywell is entitled to judgment.

The fact that Taira may have reported his medical symptoms to both Ocello and a member of the human resources team does not change the conclusion. While he may have made such reports, he did not request a reasonable accommodation for those symptoms. There was nothing “open, obvious, and apparent” to Honeywell about what limitations were required for those symptoms.

And his complaint about understaffing does not constitute a reasonable request to accommodate a disability. (See, e.g., Nadaf-Rahrov, supra, 166 Cal.App.4th at pp. 975–976.)

Cal/OSHA Guidance During Wildfire Cleanup and Recovery

In response to the ongoing wildfire recovery efforts, the Department of Industrial Relations (DIR) has posted guidance for employers and workers on how to proceed rapidly and safely as they navigate the risks associated with fire debris removal and cleanup.

Even after fires are extinguished, hazardous conditions persist. Employers involved in recovery operations within fire-damaged areas must assess these risks, address unsafe conditions, and ensure proper training is provided to all workers.

DIR is committed to protecting workers on the frontlines of disaster recovery, ensuring their safety and health as they help restore what has been lost.

DIR offers extensive information about worker health including a wildfire cleanup training tool in English and Spanish. Additional resources include information on:

Health and safety protections:

– – Physical hazards: Information is available regarding the risks of structural collapse or contact with live utilities.
– – Hazard Communication: Informing and training workers about chemical hazards from burned buildings, such as fire retardants, lead or asbestos, and other hazardous materials.
– – Cleanup, Debris Removal, and Restoration: Cal/OSHA provides guidance to employers and workers regarding proper training and equipment for safely handling debris during the cleanup of contaminated areas. Cleanup of fire damaged sites and debris removal must be done in accordance with title 8 section 5192 Hazardous Waste Operations and Emergency Response.

Wage and retaliation protections:

Workers have special rights during emergency conditions, including safety, evacuation, communication – such as access to cell phones – time off, and pay, including potential disability benefits. The Labor Commissioner’s Office (LCO) educates employers and workers about these rights, supporting compliance with relevant laws and regulations.

The LCO provides information on workers’ rights with respect to:

Protections During Emergency Conditions: Information on workers’ rights in hazardous situations, including safety measures and employer responsibilities.

– – Retaliation Protections: Safeguards for workers engaging in protected activities, such as raising health and safety concerns, refusing unsafe work, or serving as volunteer firefighters.
– – Immigration-Related Retaliation: Protections against employer retaliation based on a worker’s immigration status.
– – Wage and Overtime Regulations: Guidance on wages, overtime laws, and employer obligations.
– – Public Works: Information on labor laws specific to public works projects and prevailing wage requirements.
– – Filing Wage and Retaliation Claims: Instructions on how workers can file claims for unpaid wages or retaliation.
– – Reporting Labor Law Violations: Steps for workers to report labor law violations and seek enforcement action.

Workers in California are protected regardless of immigration status. Workers who have questions about safety and health in the workplace can call 833-579-0927 to speak with a live bilingual Cal/OSHA representative between the hours of 9:00 a.m. and 7:00 p.m. Monday through Friday. Workers who have questions about labor laws enforced by the LCO can call 1-833-LCO-INFO (833-526-4636) between the hours of 8:00 a.m. to 5:00 p.m. Monday through Friday. Complaints about workplace safety and health hazards can be filed confidentially with Cal/OSHA district offices

Motion to Arbitrate Needs Review of Arbitrator’s Discovery Rules

Prior to beginning his employment with Technology Credit Union (TCU) in 2020, Thomas Vo signed an employment arbitration agreement. Pursuant to the agreement, both parties agreed “to submit to mandatory binding arbitration any dispute, claim or controversy arising out of or relating to Employee’s employment with the Company.”

While employed with TCU, Vo contracted COVID-19 and developed long-term health issues, which persisted throughout his employment. Vo was eventually terminated and brought suit against TCU, alleging (1) harassment in violation of FEHA; (2) discrimination in violation of FEHA; (3) failure to accommodate in violation of FEHA; (4) failure to engage in the interactive process in violation of FEHA; (5) retaliation in violation of FEHA; (6) failure to prevent discrimination and retaliation in violation of FEHA; and (7) wrongful termination in violation of public policy.

TCU moved to compel arbitration pursuant to Code of Civil Procedure section 1281.21 and stay all proceedings. Vo opposed the motion to compel and argued the arbitration agreement was both procedurally and substantively unconscionable. The trial court, relying in part on Aixtron, Inc. v. Veeco Instruments Inc. (2020) 52 Cal.App.5th 360 (Aixtron), found the arbitration agreement unconscionable due to the arbitrator’s inability to compel prehearing third party discovery.

The Court of Appeal reversed in the published case of Vo v. Technology Credit Union -H051619 (February 2025).

TCU contends that the discovery clause does not render the agreement substantively unconscionable when evaluated under the discovery factors established in the Supreme Court’s recent decision in Ramirez v. Charter Communications, Inc. (2024) 16 Cal.5th 478 (Ramirez).

The Court of Appeal on its own motion took judicial notice of the JAMS Comprehensive Arbitration Rules and Procedures, effective July 1, 2014 (JAMS Rules). (Evid. Code, § 459.) JAMS Rule 17 controls prehearing exchange of information.

Rule 17(b) allows each party to take one deposition of an opposing party or individual under the control of the opposing party. (Ibid.) Any issues regarding the time, location, and duration of the deposition must be determined by the arbitrator. (Ibid.) It then states: “[t]he necessity of additional depositions shall be determined by the [a]rbitrator based upon the reasonable need for the requested information, the availability of other discovery options and the burdensomeness of the request on the opposing [p]arties and the witness.” (Ibid.)

Rule 17(d) gives the arbitrator the authority to decide all “dispute[s] . . . regarding discovery issues.” (Ibid.) The arbitrator may appoint a special master to help resolve a discovery dispute. (Ibid.)

Vo contends that the discovery provision renders the agreement substantively unconscionable because: (1) the agreement covers witness intensive employment claims, (2) the discovery terms completely bar third party discovery by excluding reference to the CAA and thereby eliminate an arbitrator’s authority to order prehearing third party discovery under Aixtron, (3) third party discovery is available in conventional litigation, (4) the bar on third party discovery advantages employers as plaintiffs cannot obtain information from relevant witnesses who work for the employer and other third party entities, and (5) an arbitrator has no authority to order additional discovery due to Aixtron. He also maintains that the JAMS Rules cannot allow for third party discovery because third parties do not contractually consent to such terms.

The Court of Appeal disagreed with Vo and the trial court and noted that “This language could have been more precise but does not limit expanded discovery to parties to the arbitration agreement or those under their control and does not preclude an arbitrator from making nonparty discovery available to the parties.” And it went on to say “the Supreme Court recently clarified that we should not construe discovery provisions defining the scope of an arbitrator’s authority “in . . . a limited way” and instead should select an interpretation that renders an agreement valid. (Ramirez, supra, 16 Cal.5th at pp. 506-507.) We thus disapprove of Aixtron to the extent it interpreted the scope of an arbitrator’s authority narrowly.

The Court of Appeal concluded that the agreement allows Vo access to third party discovery that may be necessary to adequately arbitrate his FEHA claims. The trial court’s order denying Technology Credit Union’s motion to compel arbitration was reversed. The trial court was directed to enter a new order granting Technology Credit Union’s motion and staying the litigation pursuant to California Code of Civil Procedure, section 1281.4.

Cal/OSHA: COVID-19 Non-Emergency Standards Expired

The California Division of Occupational Safety and Health (Cal/OSHA) is advising employers that most of its COVID-19 Prevention Non-Emergency Standards ended in February 2025. Cal/OSHA’s regulations took effect February 3, 2023, and remained in effect for two years, except for the reporting and recordkeeping requirements, which remain in effect until 2026.  

Although there is no longer a specific set of regulatory requirements relating to COVID-19 prevention in the workplace, employers in California must still: 

    Maintain a safe and healthful place of employment as required by Labor Code section 6400.
    Establish, implement, and maintain an effective Injury and Illness Prevention Program (IIPP) as required by Title 8, California Code of Regulations, section 3203. 
    Identify, evaluate, and correct any unsafe or unhealthy conditions, work practices, or work procedures associated with COVID-19 if they identify COVID-19 as a workplace hazard at their place of employment.

 COVID-19 reporting and recordkeeping requirements (Title 8 Subsection 3205(j)) remain in effect until February 3, 2026. The requirements specify that the employer:

    Keep a record of and track all COVID-19 cases with the employee’s name, contact information, occupation, location where the employee worked, the date of the last day at the workplace, and the date of the positive COVID-19 test and/or COVID-19 diagnosis.  
        These records must be retained for two years beyond the period in which the record is necessary to meet the requirements of this section.  
    Provide information on COVID-19 cases to the local health department with jurisdiction over the workplace, CDPH, Cal/OSHA, and NIOSH immediately upon request, and when required by law.

More information is available on Cal/OSHA’s webpage under Archived COVID-19 Guidance and Resources.

Employers with Questions on Requirements May Contact: InfoCons@dir.ca.gov, or call your local Cal/OSHA Consultation Office.  

First-in-Class Non-Opioid Painkiller Approved by FDA

The U.S. Food and Drug Administration just approved Journavx (suzetrigine) 50 milligram oral tablets, a first-in-class non-opioid analgesic, to treat moderate to severe acute pain in adults. Journavx reduces pain by targeting a pain-signaling pathway involving sodium channels in the peripheral nervous system, before pain signals reach the brain.  

Journavx is the first drug to be approved in this new class of pain management medicines.

Pain is a common medical problem and relief of pain is an important therapeutic goal. Acute pain is short-term pain that is typically in response to some form of tissue injury, such as trauma or surgery. Acute pain is often treated with analgesics that may or may not contain opioids.

The FDA has long supported development of non-opioid pain treatment. As part of the FDA Overdose Prevention Framework, the agency has issued draft guidance aimed at encouraging development of non-opioid analgesics for acute pain and awarded cooperative grants to support the development and dissemination of clinical practice guidelines for the management of acute pain conditions.  

Today’s approval is an important public health milestone in acute pain management,” said Jacqueline Corrigan-Curay, J.D., M.D., acting director of the FDA’s Center for Drug Evaluation and Research. “A new non-opioid analgesic therapeutic class for acute pain offers an opportunity to mitigate certain risks associated with using an opioid for pain and provides patients with another treatment option. This action and the agency’s designations to expedite the drug’s development and review underscore FDA’s commitment to approving safe and effective alternatives to opioids for pain management.”

The efficacy of Journavx was evaluated in two randomized, double-blind, placebo- and active-controlled trials of acute surgical pain, one following abdominoplasty and the other following bunionectomy. In addition to receiving the randomized treatment, all participants in the trials with inadequate pain control were permitted to use ibuprofen as needed for “rescue” pain medication. Both trials demonstrated a statistically significant superior reduction in pain with Journavx compared to placebo.

The safety profile of Journavx is primarily based on data from the pooled, double-blind, placebo- and active-controlled trials in 874 participants with moderate to severe acute pain following abdominoplasty and bunionectomy, with supportive safety data from one single-arm, open-label study in 256 participants with moderate to severe acute pain in a range of acute pain conditions.

The most common adverse reactions in study participants who received Journavx were itching, muscle spasms, increased blood level of creatine phosphokinase, and rash. Journavx is contraindicated for concomitant use with strong CYP3A inhibitors. Additionally, patients should avoid food or drink containing grapefruit when taking Journavx.

The application received Breakthrough Therapy, Fast Track and Priority Review designations by the FDA.

There are several other promising non-opioid pain treatments currently in the pipeline seeking FDA approval such as:

– – Esketamine: Originally approved for treatment-resistant depression, esketamine is being explored for its potential in managing chronic pain.
– – Cannabidiol (CBD): Various formulations of CBD are being studied for their analgesic properties, particularly for chronic pain conditions.
– – Tanezumab: A monoclonal antibody that targets nerve growth factor (NGF), tanezumab is being evaluated for chronic pain conditions such as osteoarthritis.
– – Zynrelef (Bupivacaine and Meloxicam): This combination drug is designed to provide extended pain relief for surgical patients without the use of opioids.

These treatments represent a growing trend towards developing safer, non-addictive alternatives to traditional opioid painkillers. It’s an exciting time in pain management research!