CRE or Carbapenem-Resistant Enterobacteriaceae is the new and frightening “superbug.” The bacteria can kill up to half of patients who get bloodstream infections, a rate much higher than other resistant infections such as MRSA or Clostridium difficile. The bacteria are also sometimes referred to as the “nightmare bacteria”
According to a report in USA Today, the deadly pattern of illnesses began to emerge in 2012 at hospitals in Seattle, Pittsburgh and Chicago. CRE is perhaps the most feared of superbugs, because it resists even “last defense” antibiotics. And in each hospital case, investigators identified the same source of transmission: a specialized endoscope, threaded down the throat of a half-million patients a year to treat gallstones, cancers and other disorders of the digestive system. They found that the devices, often called duodenoscopes, accumulate bacteria that are not always removed by conventional cleaning, so infections can pass from patient to patient.
CRE has now infected patients closer to home. The Los Angeles Times reports that nearly 180 patients at UCLA’s Ronald Reagan Medical Center may have been exposed to potentially deadly bacteria from contaminated medical scopes, and two deaths have already been linked to the outbreak. The Times has learned that the two people who died are among seven patients that UCLA found were infected by CRE – a number that may grow as more patients get tested. UCLA said it discovered the outbreak late last month while running tests on a patient. This week, it began to notify 179 other patients who were treated from October to January and offer them medical tests. By some estimates, if the infection spreads to a person’s bloodstream..
UCLA said it immediately notified public health authorities after discovering the bacteria in one patient and tracing the problem to two of these endoscopes. The university said it had been cleaning the scopes “according to standards stipulated by the manufacturer,” and it changed how it disinfects the instruments after the infections occurred. Dale Tate, a university spokeswoman, said “the two scopes involved with the infection were immediately removed and UCLA is now utilizing a decontamination process that goes above and beyond the manufacturer and national standards.”
Yet neither the scopes’ manufacturers nor the Food and Drug Administration, which regulates them, have publicized or offered guidance on the problem. So, many doctors who use the scopes – and most of the patients they treat – don’t know the risks. Nor do they know that steps can be taken to cut those risks dramatically. “Most hospitals that do these procedures are not even looking for this problem, or they may not be aware, and that’s got to change,” says Jeffrey Duchin, a physician who heads communicable disease control at the Seattle and King County Public Health Department.
The FDA says in a written statement to USA TODAY that it is “aware of and closely monitoring” the infection risks associated with the scopes. “Some parts of the scopes may be extremely difficult to access and clean thoroughly,” the agency adds, “and effective cleaning of all areas of the duodenoscope may not be possible.” The agency is studying the problem and working with manufacturers to determine whether new cleaning protocols should be mandated or the scopes should be redesigned entirely. Meanwhile, the scopes’ “lifesaving” ability to detect and treat potentially fatal digestive disorders outweighs their infection risks, the statement adds. “It (is) important for these devices to remain available.” Few dispute the scopes’ importance.
But public health officials and endoscopy experts who have studied the problem believe the FDA and scope manufacturers have been slow to bring attention to the infection risks and publicize steps hospitals can take to reduce them dramatically. “It’s fair to ask whether the FDA could have been doing more to regulate these devices and significantly reduce the risk of patient harm,” says Lawrence Muscarella, a biomedical engineer and independent consultant who advises hospitals on endoscope safety. “Patients have died, and the agency seems to be moving slowly.” .